"LYSENKO, VIEWS OF NATURE AND
SOCIETY -
REDUCTIONIST BIOLOGY AS A KHRUSCHEVITE
REVISIONIST WEAPON"
First published in pamphlet format in Toronto; September 1993.
(pp.170-212)
Continuing With:
PART TWO : LYSENKO
INTRODUCTION
In general Lysenko is roundly abused as a charlatan and
a pseudo-scientist, who manufactured biological speculations based on a
prior philosophical edifice of Dialectical materialism. This belief is
coupled with charges that he curried political favour to promote his pseudo-science.
It is true that the hostility towards Lysenko, was more than matched by
Lysenko's contempt of orthodox genetics. But in Part
One, the potted history we see that
even in Western genetics, many scientists voiced dissatisfaction with orthodoxy.
It is fair then to ask:
"To what extent, is the general assessment of Lysenko
correct as to either his biological theories, or his political influence?"
Explicitly, three main accusations
are examined in this section:
Accusation Number (i):
Charges that he was not primarily a scientist and that
his theoretical framework was incorrect. Further, this accusation states
that his biology owes more to a rigid abstract Marxist dialectics than
to nature. Moreover that he imported into a pure science, a hitherto unknown
political stance.
Accusation Number (ii):
Charges that he was responsible for the practical destruction
of a large part of Russian agriculture by an incorrect practice drawn from
an incorrect theory.
Accusation Number (iii):
charges that to promote his views Lysenko actively courted
and obtained Stalin's assistance to suppress non -Lysenkoite genetics.
Furthermore the active persecution by Terror
was responsible for Lysenko's victory, and that this Terror was guided
by Stalin's approval.
These accusations emanate from a wide variety of political
outlooks, that form a United Front against both Lysenkoism and Stalin.
This Front ranges from those with an openly bourgeois anti-Communist view,
to the politically uninterested scientists who accept received wisdom,
to the Trotskyite view that everything in Russia up to 1952 was a manifestation
of Stalin's evil influence. In their analyses, these various authors usually
do not critically examine Lysenko himself. At best, a few selective quotes
are used to display a "familiarity" with Lysenkoism. The formula used is
: Recitation of a few facts, distortion of more facts, coupled to an omission
of other information and assumptions that nuclear DNA is at the root of
all heredity.
Therefore to conduct a legitimate enquiry, we will
analyse critically at least the major parts of Lysenko's theory.
To assess this theory, we apply the test of current genetic
knowledge. This is a harsh test, as the state of knowledge in 1945-52 was
even less complete than now. The theoretical framework of Lysenko is considered
below, and this mainly considers the above numbered Charge (i).
This part then, is the "purely" biological analysis
of the charges against Lysenko. Not to pre-empt this analysis, it concludes
like many another before and after him, that Lysenko was sometimes right
and sometimes wrong.
As for the role of philosophy, and dialectical materialism
in his biology, Part 3, examines, albeit briefly, the value
or otherwise of dialectics in the sciences.
Charges (ii) and (iii) are really the political
core of the charges against Lysenko. These charges, we will assess in historical
detail in Part Four.
LYSENKO AND THE CHROMOSOMES
One of Lysenko's most insistent arguments was that there
is no special corpuscular bearer of the means of heredity. He thought of
the entire body as being in some way, capable of participating in the formation
of the progeny. This view was summarised in statements such as:
"Heredity is the property of a living body to require
definite conditions for its life, its development, and to respond definitely
to the influence of particular conditions."
p.484. Lysenko, Agrobiology, Moscow, 1954.
This view has been credited as containing the roots of Lysenkoite
mysticism. But it is interesting that non-Lysenkoist, non-Communist Western
geneticists, at odds with Orthodoxy in genetics have often expressed similar
views, at similar historical time periods. Compare for instance, Lysenko's
view with the views of Wettstein, whose work was discussed in Part
One:
"Chromosomes and cytoplasmic permeability, growth and
gastrulation chlorophyll formation and pigmentation, hairiness and habitus,
all these traits are the product of the cooperation between the genome
and the plasmon. One should therefore finally dispense with the entirely
wrong opinion, that race and species - characteristics are determined by
nuclear genes and more profound characteristics of organisation (= traits
of higher taxonomic groups) by the plasm. This is basically wrong and should'nt
be discussed again. The cooperation (between the plasmon and the genom)
is the essential point."
Cited by Sapp,Ibid. p. 76.
Or compare Lysenko's expression with that of Wettstein's
colleague Michaelis:
"We can assume that the cytoplasm is not simply the sum
of cytoplasmic units but a complicated hereditary system in which the units
participate-in various, still unknown ways- in the composition and structure
of the cytoplasm. Not only do the various component of the cells form a
living system, in which the capacity to live, react and reproduce is dependent
upon the interactions of all the members of the system; but this living
system is identical with the genetic system. The form of life is determined
not only by the specific nature of the hereditary units but also by the
structure and arrangement of the system. The whole system is more than
the sum of its parts and the effects of each of the components depend on
and is influences by all previous reactions, whose sequence is in turn
determined by the whole idiotype."
Cited by, Sapp, Ibid, p. 78-9.
For a final 20 th century viewpoint, Barbara McClintlock
can be cited. But perhaps the final comparison should be with the view
of the Founder of the Neo-Synthesis, Charles Darwin:
"Inheritance must be looked at, as merely a form of growth."
Charles Darwin, 1868, p. 404. Cited Sapp, p. 3
Of necessity, Three
Main Corollaries must follow this general
view, of the intricate linkage between events in the cytoplasm and the
nucleus.
Firstly, this view emphasises the genetics of the
body as changing, as "responding", as "growing". On this question Lysenko
was correct, and his assertions are at least in part, vindicated by current
day research. This has been addressed in the latter part of Part 1.
To remind us of one thought that emphasises biological
changeability and responsivity, McClintlock found herself in opposition
to orthodoxy for precisely her insistence upon the organism's flexibility:
"In its original form the Central Dogma offered no way
to account for the fact that the specific kinds of proteins produced by
the cell seemed to vary with the cell's chemical environment."
McCLintlock, cited by Keller, p.7
The Second Corollary is that Lysenko's position would
support the position that the Inheritance of Acquired Characters
is possible. This has in part already been addressed in Part 1, and the
work of the Western scientists such as Sonneborn have been cited
to support this view. Especially in the plant kingdom, we have shown enough
data, that the absolute interdictions against Inheritance of Acquired Characteristics,
violates the facts.
The Third corollary applies to Lysenko, but not
to Wettstein, Michaleis and McClintlock.
It concerns the existence of chromosomes, and
more importantly their role.
This has to be examined, since Lysenko offers them virtually
no scope in heredity by the above definition.
In our view, there should be no doubt that Lysenko therefore
radically overemphasised the view that there was no
biochemical function in heredity for the chromosomes. In this he was mistaken
we would contend.
But it is often asserted that the Lysenkoists
rejected any role in the cell for the chromosomes.
This is NOT wholly correct; for at various times
the significance of the chromosomes was explicitly recognised by Lysenko
himself:
"Naturally.. we do not deny the biological role and significance
of chromosomes in the development of the cells and of the organism. But
it is not at all the role which the Morganists attribute to the chromosomes."
p.22, Address By T.D.Lysenko, to the Lenin Academy.
"Where did they get the idea that we deny the importance
of the nature of plants.. the importance of the genotype."
Lysenko, In Agrobiology p.187.
"They think that by denying that the morphology of the
chromosome plays the sole and exclusive role we deny matter."
p.183, "Agrobiology" "Two Trends in Genetics."
It is evident from these quotations, that in fact ONE
thing that Lysenko attacked was the very same simple minded concepts, that
were attacked by Western geneticists such as McClintlock, Goldschmidt,
Sonneborn and others. But in so doing he did at times inveigh too heavily
against the physical material
structures:
"We deny that the geneticist and the cytologist will
see genes under the microscope."
Lysenko; Ibid, p.187.
But of course, Lysenko lost his crystal ball somewhere. Because
of course, here Lysenko was incorrect. Years later, genes were visualised
by X-Ray diffraction. Moreover, the cells in which various genes are acting
can be visualised by locating the messenger RNA with its corresponding
DNA.
And again, he dogmatically insisted in a radical over-emphasis
that:
"Every living particle or even droplet of a body (if
the latter is liquid) possesses the property of heredity, ie. the property
of requiring relatively definite conditions for its life, growth and development."
Lysenko 2, p. 417, "Heredity And its Variability", In
"Agrobiology" Moscow, 1954.
However, in arguing against any role of the chromosomes
in heredity, the essential thrust of Lysenko was to retain the possibility
of, and indeed necessity of change:
"They have endowed these particles of heredity with a
property that not a single molecule of the living organism possesses, namely
the property of not developing".
Ibid, p.219.
Lysenko selects for attack notions of unchangeability:
"Koltsov asserts:
"Chemically the genome with its genes remains unchanged
in the course of the entire oogenesis and is not subject to metabolism
- oxidation and reduction processes."
This assertion, which no literate biologist can accept, denies
the existence of metabolism in a section of the living and developing cells.
It must be obvious to everyone that N.K.Kotsov's conclusion is fully in
line with the Weismannist and Morganist idealist metaphysics.. For further
proof.. Schrodinger (ed - In "What is Life? The Physical Aspect
of the Living Cell." E.Schrodinger, 1945, Cambridge, p.85.) ..asserts
that there exists an " hereditary substance, largely withdrawn from the
disorder of heat motion."
Lysenko, speech to Lenin Academy, Ibid, p.23
As discussed above, these anti-change notions of Koltsov
are fundamental to the Weismannist statist view of nature.
But even given Lysenko's need to defend the idea and
possibility of change as a force in nature, certainly some of his followers
adopted an approach that ended up throwing out the baby with the bathwater.
Thus S.S.Perov in upbraiding one Professor Alikhanian
states categorically:
"Hormones are extremely complex compounds that are secreted
by special organs - the internal secretion glands. Only a scientist who
has resolved to commit scientific suicide can go to the extent of conceiving
the gene as an organ, a gland, with developed morphological and very specific
structure. To conceive that the gene which is part of the chromosome, possesses
the ability to emit unknown and undiscovered substances and, although not
being a biochemist, to declare that these substances are hormones, means
indulging in metaphysical extra-experimental speculation, which is fatal
to experimental science."
Quoted in Third Sitting at the Lenin Academy. Speech
by S.S.Perov, Ibid, p.142-3.
Others were far more literal than Lysenko in the rejection
of the gene and the chromosome. Thus K.Y.Kostryukova asserted that:
"You may see under an electronic microscope whatever
minute particles you like, but they will still be nothing other than particles
of a chromosome, and you will never see a gene, for there is no such thing,
no more than there is a vital force."
Cited, Ibid, p.323.
Even the demonstrations by the adherents of the plasma
gene were not sufficient to convince or mollify Kostryukova:
"True they now say that genes are also to be found in
the plasm of the cell. But that does not alter matters essentially. The
plasmagene and the chromosomal gene are both made of the same peculiar
hereditary substance. Such peculiar, concocted substances or forces were
known in many other sciences at the initial period of their development.
They were intended to provide an explanation for phenomena which could
not be explained by at a given stage of development of this science.. recourse
in biology, was had to a vital force.. some kernel, hereditary substance..
It is this hypothetical substance that is studied by geneticists. They
even connect it with a material substratum, the chromosomes and see therein
the confirmation of its existence. This however does not deprive this substance
of the qualities that distinguish other invented substances. The hereditary
substance that is set against living matter exists no more than do either
the calorie or the phlogiston."
Kostryukova, Ibid.
But. before we pass any judgement on Lysenko and his school,
we should bear in mind the discomforts of the Western geneticists like
McClintlock and Goldschmidt, with the Morgan-Weismann-Mendel views that
became the "Central Dogma"; as cited earlier.
But in addition, we should re-examine the basis of Mendelian
genetics.
These were the Laws of Segregation that Lysenko rather
arrogantly and degradingly asserted were "The Pea Laws". These Laws
of Segregation were key to the New Synthesis. But there was a lack of dovetailing
of theory with many experimental observations, as was discussed in Part
One.
We will briefly re-cap some of the key findings.
NON-MENDELIAN INHERITANCE
Perhaps one of the earliest observations, that served
effectively to challenge Mendelian segregation, as a universal phenomenon
- was made by Correns :
"In the .. Four O'Clock or Marvel of Peru, some variants
with yellowish-green or variegated leaves showed normal Mendelian segregation,
while a particular variant albomaculata, with yellowish-white variegation
did not. Plants of the variant albomculata produced occasional shoots which
were wholly green and other which were white ; flowers on green shoots
gave only green progeny whether pollinated from flowers on green, white
or variegated shoots, and conversely flowers on white shoots whatever the
pollen plant, gave only white progeny( which died in the seedling stage
".
p.104 Briggs and Walters.
Other instances arose where a convenient Mendelian inheritance
pattern was simply not tenable. This includes the inheritance of variegation
in Maize uncovered by Rhoades in 1943:
"The variant 'iojap' with.. striped leaves, was found
by Jenkins in 1924 to be caused by a single recessive gene. Using 'iojap'
plants as male parents he found the .. expected ratio of 3:1 of normal
'iojap'. Rhoades.. showed in 1943, that female 'iojap' plants gave.. widely
varying proportions of green, white and 'iojap' phenotypes.. in the offspring
of these plants, .. unrelated to the constitution of the male parent. Rhoades
.. postulated that the gene for 'iojap', when homozygous, causes stripping
of the leaves by initiating a process which is then inherited through the
cytoplasm. Since the cytoplasm is for all practical purposes entirely derived
from the female parent, this condition shows maternal inheritance."
Briggs and Walters ibid. p. 104-5.
Other examples of similar phenomena tending to an anti-Weismannist
interpretation are cited by Briggs and Waters. They comment that:
"Although the details differ, they are generally open
to the explanation that there are hereditary particles in the cytoplasm
which can replicate sometimes indefinitely. In the case of the variegation
effects, the plastids themselves, which contain the green colouring matter
chlorophyll are self replicating structures in the leaf cells and might
therefore contain hereditary particles. Not all cytoplasmic inheritance
concerns chlorophyll containing plastids however; it has been shown by
repeated back-crossing with species of Willow Herb ( Epilobium) that 'alien'
cytoplasm of one species can persist and give a variety of genetic effects
with the nucleus of another species (Michaelis 1954)."
Briggs and Walters Ibid, p.105.
The implications of this are transparently abhorrent to strict
Weismannists. However to those not so inflexible they carry some explanatory
powers. As pointed out by Briggs and Walters:
"In general plants show greater phenotypic variability
than is found in species of higher animals. In animals individual variability
is apparently held within very tight bounds by the early precision of mechanisms
determining irreversibly the form and relationship of the main organ. To
some extent this is true of plant structure but there is a very important
difference between the plant and the animal, which resides in the fact
that there is persistent meristem or growing point tissue in even the most
short-lived of ephemeral plants, on which a succession of organ of limited
growth is initiated. The result of this difference is that the individual
plant is open to much more environmentally induced variation over a much
greater part of its life than is the animal."
Briggs and Walters, Ibid. p. 106.
"If material of a given genotype is divided into separate
pieces (ramets) and grown in two or more different environments, different
genotype-environment interactions may be produced. While the plant responds
to the environment as a whole, it is possible, by appropriate experiments
involving changes in particular factors, to deduce that certain elements
are of particular importance.. In their competition with one another in
experimental or natural communities, plants show many diverse interactions,
for example to the effects of shading.."
Briggs and Walters, Ibid, p. 107.
INTERIM CONCLUSION
Lysenko was undoubtedly correct in his assertion that
the chromosome/gene was not inviolate from cytoplasmic and thus environmental
influence.
This is particularly the case in plants.
However it is unlikely that this is restricted to plants
alone.
As a result the phenotype is not solely dictated by the
nuclear genome as the Morgan school contended. This was later shown by
such work as that of McClintlock.
The complexity of the interaction between environment
and the control of gene expression was beyond the understanding of either
the classic geneticists or the Lysenkoist.
However, Lysenko's insisted first and foremost upon
the notions of change.
In this question, he was a true follower of Heraclitus
- the great apostle of "change" -here (see Appendix Two).
BUT:
There was on the other hand a tendency of the Lysenkoist
school to underplay the relevance of the chromosomes. This led to a ignorance
of the potential role for nuclear genes and their potential manipulation.
This of course underlies some of the dramatic advances
by which medicine and technology are currently are being changed.
Here the Lysenkoists lapsed into a materialism that was
anti-dialectical because it denied a reality.
They concentrated on their laudable aim of highlighting
change.
In obeying Heraclitus, they threw the baby out with the
bathwater.
They were one sided in a most serious breach of the 4
th law of dialectics.
They in effect were "Mechanical
Materialists" (See Part III).
2. DIRECTED CHANGE
Lysenko believed that evolution changes heredity, almost
only in a directed manner.
In contrast, the orthodox New Synthesis views that evolution
only exerts its effects through chance, via Natural Selection.
Lysenko further believed that it is possible to intervene
and actively change heredity in a number of ways. Evidence for this belief
is examined below. It encompasses a number of differing botanical phenomena,
and in the ensuing discussion some agricultural realities of the USSR will
be explored also.
In passing we should say, that Lysenko contradicts himself
on the role of Chance in nature. Thus we have discussed in detail in Section
One, the issues around Chance, and their importance in the debates on Evolution.
In some places Lysenko agrees that:
"In nature the evolution of plants and animals proceeds
thorough random changes in the old heredity, through the fortuitous building
and fixation of a new heredity".
Lysenko, "Heredity and its Variability" , in Agrobiology,
Ibid.p. 429.
However elsewhere the conventional geneticists were castigated
for their adherence to Chance. Thus in his Address
to the Lenin Academy in 1948, he said:
"Gene mutations according to the theory of Mendelism-Morganism
appear fortuitously. Chromosome mutations are also fortuitous. Proceeding
from these invented fortuities, the Morganists base their experiments too
on a fortuitous choice of substances that might act as mutagenic factors.,
believing that they are thereby acting on their postulated hereditary substance
which is just a figment of their imagination, and hoping to obtain fortuitously
what may by chance prove to be of use.. In general living nature appears
to the Morganists as a medley of fortuitous isolated phenomena, without
any necessary connections and subject to no laws, Chance reigns supreme.."
p. 551, Ibid, in Agrobiology.
His invocation in general was:
"We must firmly remember that science is the enemy of
chance. That is why Michurin, who was a transformer of nature, put forward
the slogan: "
We canot wait for favours from Nature; we must wrest
them from her."
Lysenko, Address to Lenin Acadmey, In "Agrobiology",
Ibid, p.552.
In this regard we should examine how he thought this could
be done.
(A) HYBRID VIGOUR.
Lysenko stressed in his work a phenomenon that had
been well described by Darwin, and became termed Hybrid Vigour.
This was a phenomenon whereby established varieties,
of plants, would undergo a deterioration in breeding proliferative potential:
"Nearly every plant breeder has in small plots and nurseries,
or in variety test plots, some varieties that compare favourably.. yet
many breeders are rarely able to release a variety for production.. because
of deterioration of varieties.."
Lysenko, Ibid, p.139.
"Usually.. the deterioration ...has been attributed to
flaws in the experiment, in other words, to errors..I arrived at the conclusion
that the deterioration of new varieties.. is often due to the degeneration
of their inherent genetic state.."
Lysenko, Ibid, p.140
His observation was one that he claimed:
"Every plant breeder knows ..that a good first hybrid
generation is not in itself guarantee that a good variety will be produced
..."
Lysenko, Ibid, p.141.
The problem that he described he felt was:
"One of the fundamental problems of plant breeding ...the
fixation of the genotype..."
Ibid; p.141.
It will be seen below that Lysenko was right in an empirical
observation, that the phenomenon was due a "degeneration of the inherent
genetic state".
However, he could provide no real mechanism for this
degeneration.
And the mechanism is one that does in fact rest upon
an acceptance that Mendelism must be sometimes correct !
But Non-Lysenkoist scientists apparently objected to
Lysenko on the issue of Heterosis upon two principal grounds.
a) Does Heterosis Exist ?
Critics argued that the phenomenon, if it existed was
not such an important phenomenon. They argued that self-pollinating plants
do not deteriorate. The explanation for the observed habit if the peasants,
who changed their crop variety every few years; was due to the better crop
varieties that became available.
However the phenomenon had been long noted by plant breeders.
It had drawn Darwin's attention. Indeed the phenomenon itself had been
noted since early breeding experiments, by others as well:
"If plants of pure lines originating from different parental
stocks are crossed together, hybrid vigour - so called heterosis - may
be demonstrated. Such plant are characteristically of great vegetative
vigour and high fertility...The phenomenon of heterosis, so pronounced
in experimental crosses with inbred lines, was not a new discovery, being
often reported in the studies of early plant hybridists (Roberts 1929)..."
Briggs and Walters, Ibid, p. 134-5.
In his great search for the possible evidences for evolution,
Darwin had been led to try and understand the function of flowers.
In particular the fascinating forms of the Orchid, then a fashionable craze
in England, seemed to be dictated by some need.
Darwin rejected the prevalent notion of complexity arising
by God's wondrous attention to beauty. Darwin wrote in puzzlement in 1876:
"It often occurred to me that it would be advisable to
try whether the seedlings from cross fertilised flowers were in any way
superior to those from self-fertilised flowers. But as no instance was
known with animals of any evil appearing in a single generation from the
closest possible interbreeding, that is between brothers and sisters, I
thought that the same rule would hold good with plants.."
Cited, Briggs and Walters. Ibid. p. 116
But Darwin went on to test his hypothesis and was surprised
to note, in 1866, with his beds of Linaria vulgaris that:
"In two large beds of seedlings of self-fertilised and
cross-fertilised individuals..the 'crossed ' plants when fully grown were
taller and more vigourous than the self-ed progeny. Darwin's interest was
thoroughly aroused and he investigated over the many years the effect of
cross and self-fertilisation in a number of species, eg. Ipomoea purpurea,
Mimulus luteus, Digitalis purpurea, Zea mays. He gave great attention to
experimental design.... he examined one of a number of measures of performance
such as height, weight or fertility.. As a result of his experiments which
were a landmark in the study of breeding behaviour, Darwin was able to
see how the enormous range of floral types and physiological differences
in behaviour such as different times of maturity of stamens and stigma
on the same flower, could be viewed as adaptations to ensure cross-fertilisation
(See Attached Figure below for a common example often cited to illustrate
this - Ed). Why it might be beneficial for progeny to be cross bred rather
than the product of self fertilisation Darwin was unable to decide.."
Briggs and Walters, Ibid, p.116-117.
FIGURE: p.123 Briggs and Walters.
Two Forms of a flower, Primula
veris.
Heterostyly. ie two forms of
style in the flower ensure cross pollination.
The contradiction between the presence of self fertilising
mechanism in nature for plants and the better yields of agricultural heterotic
plants may be only an apparent, and not a real stumbling block. The advantage
of self-fertilisation would be a fail safe mechanism, whereby it woudl
be ensured that a seed could be set - even if there was no outbreeding
possible:
"One possible advantage of repeated self-fertilisation
might be that well adapted genotypes could be replicated without change.
A further advantage especially in extreme or marginal habits where crossing
between plant might be hazardous or fail altogether, is that self-fertilisation
is a safe method of producing offspring."
Briggs and Walters, Ibid. p.137.
But as Briggs and Walters point out:
"An appreciation of the long-term disadvantages of inbreeding
enable us to recognise the advantages of the outbreeding method of reproduction.
As we have seen, structural features or physiological mechanisms prevent
or discourage self-fertilisation and lead to crossing between different
individuals. Such breeding will tend to generate a good deal of genetic
variation."
p. 137 Briggs and Walters.
b) The Mechanism of Heterosis
Those Soviet scientists that accepted the phenomenon
of Heterosis as being real; only did so on the grounds of Mendelian
segregation. Lysenko argued that the geneticists were constantly redefining
the rules, and adapting data to fit into their own structure:
"True it will be nothing new to me if the geneticists,
who now dispute with the propositions I advance, will in the future, when
they have been confirmed and their value demonstrated in practice, try
to explain this phenomenon as being in tune with their theory of the corpuscular
nature of the hereditary substance. They can do this with exceptional ease
in relation to varieties of hybrid origin. They attribute it to quite ordinary
segregation.. In general the concepts which the geneticists include in
the term "segregation" can never serve to explain anything. By segregation
they mean merely the mechanical disjunction, separation of ready made corpuscles,
genes which always, from the zygote to reduction division, lie opposite
each other. To us, who regard the living organism in its development, ie
in its changes and transformations, the unsoundness of the concepts which
the geneticists include in the term "segregation" is absolutely clear."
Lysenko, Ibid, p.142.
"The explanation that the geneticists.. give of the case..
of part of the progeny.. from the spike of a spring wheat plant is of winter
habit and part is of spring habit.. is that hidden within the initial spring
plant were granules of substance (genes) which facilitate the development
of only the property of winter habit, and that in addition to this substance,
there lie in another chromosome granules of another substance other genes,
which facilitate the development in plants of only the property of spring
habit. Since experience shows that this is a spring plant, they claim that
the granules of substance which determine the spring habit repress their
partners - the granules of substance which determine winter habit .. this
is how the geneticists answer the rather difficult and at first sight incomprehensible
question of why a spike of a spring wheat plant (SAW from cross
of winter and spring forms) yields seeds that produce both spring and winter
plants. This is solely the explanation of all the other differences among
hybrid plants. As we see their line of argument is a simple one.. The geneticists
are not in the least disturbed by the fact that nobody, not even the geneticist
experimenter himself has detected this property (winter habit) in the spring
plant that was investigated. They draw the conclusion that this property
of winter habit is present in the form of granules, only if it does not
manifest itself either externally to the eye, or by means of any other
analysis of this plant. They even say that they know the place in the cell
were this special substance (genes) is situated ."
p.145 Lysenko ; " Agrobiology", 1954.
As discussed above, the phenomenon itself is a genuine
phenomenon and is not any longer, usually contested. So Lysenko was correct
in his general assertion here.
However, the explanation of hybrid vigour that is currently
available to biologists may not be terribly pleasing to the die hard Lysenkoists.
It appears that:
"In the heterozygous diploid the dominant allele, often
shelters recessive alleles which are deleterious in the homozygous state.
Self fertilisation quickly results in the segregation of lethal or sub-lethal
types as homozygous recessive are produced. Unless specially looked for
in the seedling stage these types which may die at an early stage of growth
may be undetected even in garden or glasshouse culture. Further selfings
produce rapid separation of the material into uniform lines - often called
pure lines - differing from each other in various vegetative and reproductive
characteristics. The continued selfing of uniform lines may be rendered
impossible as some plants may become weak or sterile. Surviving lines may
by characterised by plants of reduced fertility and vigour."
Briggs and Walters, Ibid, p. 134-5.
So though the phenomenon was real, because of his bias
against Mendel and the notion of a gene, Lysenko was in no position to
appreciate how the phenomenon may arise.
Lysenko's own crossings were probably based on the underlying
principle of natural selection. ie. The best available specimens should
be crossed, and the most vigourous progeny should be cultivated. This sound
agronomical practice is not unreasonable. But Lysenko was in this matter
unable to transcend it. However, it must now be asked, of what practical
importance to the USSR was this debate?
(c) The practical import of
heterosis in the USSR; -the story of hybrid corn.
Nikolai Vavilov wished to introduce hybrid corn
to the USSR. It's use in the USA had by then increased yields by 20-30%
on:
"Millions of acres. The hybridization program was organized
by Vavilov and his collaborators, and AIPB had already a number of usable
inbred lines. But this .. met the sharp resistance of Lysenko, Prezent,
Ol'shansky and others who kept discrediting it without any substantiation
whatsoever." Zhores Medvedev, "The Rise and Fall of Lysenko" ; New York,1969.
p.64.
In the USA, agronomists had developed a hybrid corn practice,
that was interestingly, based on very similar views to those of Lysenko
on hybrid vigour.
It is perfectly true that hybrid corn had boosted yields
of corn considerably in the USA; and this legitimately excited Vavilov.
The issue of monoculture became particulary controversial
when Khrushchev pointed out the merits of the US Dept of Agriculture monoculture
experiments with maize. In fact Edward Murray East and George Harrison
Schull in the USA had obtained promising results with " controlled
fertilisation ". These basically entailed detasseling of corn in order
to control the pollination, a procedure in essence similar to the ones
used by Lysenko in the USSR. East and Schull established special hybrids
of corn by breeding selected corn, because:
"Inbreeding depressed corn yields. They .. discovered
that crosses between inbred lines produced great yields, or what is called
"hybrid vigour".
Jack Doyle. "Altered Harvest" , New York, 1985.p.37.
But the story does not end here. This original observation
of hybrid vigour, or heterosis; was actually ignored by the USDA. They
then had to deal with these so called hybrid corns. The difference from
the Lysenkoite view was that they continued to use these hybrid corns exclusively;
allowing the original "hybrid vigour" to decline.
As Briggs and Walters pointed out above this will lead
to a narrow line of self contained gene pool, with some unhelpful
consequences (See quote above). Ultimately this led to the problems faced
by the corn industry in the USA, where widespread chaos and disruption
to the corn future market was caused by Corn Leaf Blight in the
1970's:
"The US Dept of Agriculture (USDA) was caught completely
off guard by the blight.. the Southern Corn Leaf Blight devastated 15 %
of America's 1970 corn crop, reducing the average national corn yield from
83.9 to 71.7 bushels per acre, costing farmers about $1 billion in, losses..
Said University of Illinois plant pathologist A.L.Hooker:
"Dry weather reduced disease spread in the Western Corn
Belt and delayed Northward spread of the disease on the Eastern seaboard.
In addition, because of favourable climatic conditions, Northern states
had above normal yields. Without these two features, national disease losses
could have been greater."
Doyle, Ibid. p.5-7.
One reason for the rapid spread of the Blight was found to
be a cytoplasmic gene (of irony
in this debate between the advocates of Weismannist central dogma and those
in favour of a role for cytoplasmic based inheritance!) that had been first
observed in the Philippines, but the reports were scouted by the US National
Academy of Sciences (NAS). The USA NAS proceeded after the devastation
to inaugurate a series of studies. These were published as: "The Genetic
Vulnerability of Major Crops" in 1972. This assessed uniformity of crop
to be a major factor in the Corn Blight. In 1976 the US NAS published a
paper which acknowledged:
"In the 1960's it became clear that relatively few corn
breeding parents were being used to produce the bulk of American hybrid
corn varieties.. the narrowness of the germ plasm set the stage for potential
vulnerability to disease insects, and other stresses. In early 1970, environmental
conditions in southern and Northern central corn producing regions were
favourable for early disease establishment and spread among vast plantings
of highly uniform varieties. the Southern Corn Leaf Blight epidemic became
of national and international significance."
Cited Doyle, Ibid. p. 15.
Finally, it should be
pointed out that a naive extrapolation from experience in the USA to that
of the USSR is dangerous. The extraordinary geography of the USSR, and
its climatic harshness puts the agricultural efforts of the Bolshevik years
(under Lenin and Stalin and excluding the Khrushchev revisionist years)
into a favourable perspective. It is important to understand this in connection
with the debate about Heterosis and pure bred Maize lines, but it applies
with strength to the other crops, such as cotton and sugar beets.
We should expand a little on the geography. The reader
is referred to the Geographic map below for easier comprehension of the
following rather lengthy section. Levins and Lewontin have shown the way,
and point out that:
"There can be no understanding of Lysenkoism that does
not begin with the hard facts of climate and soil in the Soviet Union,
Since it is usual within and without the Soviet Union to compare Soviet
and American agricultural production, it is illuminating to compare Soviet
and American agricultural production, Nearly all of the USSR lies above
the latitude of St.Paul Minnesota (40 Deg N) so its general temperature
regime is more like that of the Western Canada than that of the US. The
growing season in the most productive belt the Chernozem, is short, and
the contrast between summer and winter temperatures is extreme, as compared
with Western Canada and the USA. Although the population of the Soviet
Union is one-third larger than that of the US, the total harvestable acreage
per year is the same about 360 million acres. The rich black chernozem
soils of the USSR, equivalent to the Great Plains and prairie of the US
and Canada are in a narrow east-West belt from the Ukraine in the West,
passing just North of the Black Sea, to Akmolinsk in the East, running
roughly along the 50th Parallel. South of the Chernozem belt rainfall is
10 inches or less per year and so is much too arid for normal agriculture,
North of the chernozem belt rainfall is 16-28 inches per year , quite adequate
for agriculture but the soil is poor the growing season short and the winter
frosts very severe, so neither winter wheat nor spring wheat is favoured.
The problem for farmers in this region is to plant late enough to avoid
killing frosts, yet early enough to get a full growing season, The Chernozem
belt itself, which is the chief agricultural region of the Soviet Union,
lies in band of marginal rainfall, 10-20 inches per year, with frequent
droughts that result in catastrophic crop failures. In contrast, the back
soil belt of the US runs North to South in the Great Plains, spans a broad
range of temperature regimes, mostly milder than in the USSR, and receives
15-25 inches of rainfall per year, reaching 30 inches in the Easternmost
sections. In addition a large central section of the US, just East of the
Plains, had 30-40 inches of rain, soils 3-10 feet deep, a long and mild
growing season with summer nights that do not fall below 55 Deg F, that
is ideal for maize. This corn belt which is the basis for meat production,
is completely absent in the USSR... these generally poor conditions in
the Soviet Union are similar for other crops. Cotton which in the US is
chiefly produced in the most regions of the Southeast by dry farming, must
be irrigated at considerable expense in the Soviet Union, since warm temperatures
are accompanied there by semi-aridity. The most striking example of the
deleterious effect of environment on a staple crop is sugar beets.."
Levins and Lewontin, Ibid. p. 171-172.
These authors make the pertinent conclusion that:
"Lysenko's rejection of hybrid corn and his insistence
on the use of locally adapted varieties usually is offered as a prime example
of the counterproductive effects of his unscientific theories.. while Khrushchev
is praised for adopting American hybrid corn breeding. Yet hybrid corn
has not been a success in the Soviet Union, precisely because there is
no corn belt. In the US outside of the corn belt, in areas that are more
marginal for maize, locally adapted varieties commonly outperform hybrids."
Levins and Lewontin, Ibid, p. 172.
MAP USSR SHOWING VEGETATION ZONES.
From Knystautas, Algridas :
The Natural History of the USSR", Century Hutchinson, London, 1987; p.32.
The map shows well the vast
range of the climactic zones that are necessary for the climate to vary
from polar zone and tundra, to desert, to mountain.
In part 4,
we explore in more detail the realities of crop production in the USSR,
and the destruction of USSR agriculture under the Khruschevite revisionists.
Conclusion :
In summary,
hybrid vigour is a real phenomenon that was correctly identified by Lysenko
as a key factor in crop productivity. The resistance to recognition of
its importance its' may have prevented a rise in corn production earlier
in the USSR. The campaign by Vavilov and later Khrushchev, to rely on special
hybrid corns was based on a mistaken belief that these selected corns were
by themselves adequate to boost production. A parallel experiment in the
USA contradicts this view. The exclusive reliance on hybrid corn in the
USA led to a major crisis in the resistance of the US corn to infection,
again highlighting the importance of the phenomenon of hybrid vigour.
(B) VEGETATIVE PROPAGATION
AND GRAFTING
It is largely accepted that grafting is a crucial part
of common agricultural practice.
However Lysenko's view was that using grafts one could
permanently alter the genetic
properties of the stock and scion.
It is interesting then that there is substantial evidence
from non-Lysenkoist sources
that this may be a method of transmitting characteristics:
"A special form, one with a long history of pre-Lysenko
history, of the inheritance of acquired characteristics is graft hybridization,
in which grafted plant acquire and supposedly transmit some of the characteristics
of their graft partner. Grafting is most effective if done at an early
stage of development. Thus techniques such as transplanting plant embryos
to the stored seed nutrient endosperm of other varieties or producing different
endosperm by using mixtures of pollen provide the most favourable conditions
for vegetative hybridization. The equivalent process in animals is the
use of mixed sperm; the sperm that penetrate the egg without actually fertilizing
the nucleus metabolize for a while and serve as an internal mentor or guide
to development. Bailey discussed the use of graftage in plants and animals
and added:
'There are certain cases however, in which the scion
seems to partake of the nature of the stock; and others in which the stock
partakes of the nature of the scion. There are recorded instances of a
distinct change in the flavour of the fruit when the scion is put upon
the stock which bears fruit of a very different character. The researches
of Daniel (1898) show that the stock may have a specific influence on the
scion, and that the resulting changes may be hereditary in the seedlings."
Richard Lewins and Richard Lewontin. The Dialectical
Biologist. Harvard, 1985. p.177-8.
An interesting case that interacts with the notion of the
developmental timing of changes in phenotype (See below), is the special
case of grafting of the tips of Hydera helix, the Common Ivy. We have already
discussed this, See Prior Figure (p.107; in hard copy version):
"The wild plant common in Britain and Atlantic Europe,
shows a very marked heterophylly, the familiar lobed 'ivy-leaf' being produced
exclusively on non-flowering shoots which are normally flattened or adapted
for growth attached to trees or on the woodland floor., The flowering shoots,
in contrast are erect, branch more or less radially, and bear simple leaves.
Intermediate shoots are rare (See figure ). Seedlings as would be expected,
produce lobed leaves and quickly assume the vegetative phase. If however
portions of either vegetative or reproductive shoots are detached and rooted
separately, the plants so produced normally continue to grow in the manner
characteristic of the particular phase. This is apparently true even of
intermediate shoots, In this way, whole plants of Hedera with o more or
less erect habit and simple leaves can be propagated, apparently indefinitely,
though 'reversion' to the juvenile phase can be induced by repeated cutting,
by grafting of the juvenile stock, or by spraying with the growth substance
gibberellic acid. In such a case we appear to have a condition which is
explicable neither in terms of genetics nor in the terms of direct effects
of the environment on the phenotype. Brink (1962) and others have postulated
self-replicating factors in the cytoplasm to explain such phenomena, and
have pointed out although Hedera is a specially familiar case, there is
a whole group of phenomena in woody plants which are not essentially different
and which have not yet understood. A useful review is provided by Doorenbos
(1965)."
Briggs and Walters, Ibid. p. 109.
In the Soviet Union there was a scandal over the demonstration
of a case of fraud. This entailed a hornbeam
graft.
It was contended that the graft showed some fraud.
The case was initially denied by the Lysenkoists, but
the agriculturist who made the graft publicly acknowledged that it had
been a graft.
CONCLUSION
Lysenko was in general correct, when he was highlighting
the practical importance of grafts.
C) PHYSICAL INTERVENTIONS
AT CRITICAL JUNCTURES.
Lysenko strongly believed that interventions at particularly
sensitive times of the embryo's development would alter the properties
of the developing organism. This was the basis for his strong endorsement
of the process of Vernalisation.
In this matter he has been criticised by many authors
on two grounds.
Firstly, that he did not actually invent this process,
that credit should go to a German by the name of G.Gassner. Loren
Graham points out that Lysenko was aware of Gassner's work and fully credited
him (Graham. p.202).
But more fundamentally he has been attacked on
the grounds that the process of vernalisation itself did not work, and
that it was a lot of scientific baloney. It seems somewhat two sided. You
cannot say on the one hand that Lysenko stole the idea, and on the other
say that in any case he was wrong.
Moreover, Sapp points out some interesting corollaries
between Lysenko's work and the directions of other Western researchers:
"Lysenko's central technical work on vernalization was
substantial and has often been overlooked by modern commentators (Rolls-Hansen,
1985). In fact, vernalization was similar to the technique developed by
Goldschmidt and Jollos. Goldschmidt continued to see the " remarkable
features of vernalization in cereals "to be a threat to Mendelian orthodoxy:
"By appropriate treatment (eg with cold) at the proper
time the physiological alterative can be induced; for example, winter wheat
can be made to behave like summer wheat. This may be described as a induced
self-perpetuating cytoplasmic change. Self perpetuation may mean.. the
presence of changed self-perpetuating bodies like mitochondria, but it
may also mean a strictly alterative chemical property of the cytoplasm
(a "steady state"), which remains until forced again into its original
condition."
Cited by Sapp J; p.168.
In this matter then, later developments have forced a consideration
of the role of the cytoplasmic hereditary determinants contained within
the plastids of plants. This has been discussed above under "Non-Mendelian
Inheritance".
Even the generally critical Loren Graham states
that:
"The treatment of seeds before or after treatment does
permit under some conditions the shortening of the vegetative period and
growing of winter varieties of grains during the summer. This technique
was known in the US as early as 1854 and ..Germany.. And the fact that
seeds of various kinds of plants require certain conditioning periods,
during which temperature and moisture are critical factors m has been a
commonplace in the field of plant propagation for decades. The actual processes
that take place within seed before germination are extremely complex and
are even as yet far from being fully understood.. involving complex biochemical
and physical changes."
Graham, Ibid. p. 202.
Graham does charge however, that Lysenko was a sloppy experimenter
with inadequate controls for his experiments:
"The more spectacular of Lysenko's vernalization claims
can probably be accounted for by the impurity of Russian plant varieties
and by Lysenko's extremely small samples. The best known example of his
conversion of winter wheat into spring wheat is the case of the Kooperatorka
winter wheat. Lysenko himself called it in 1937 " our most prolonged experiment
at the present time "...On March 3, 1935, Lysenko sowed this variety of
winter wheat in a greenhouse until the end of April at a very cool temperature,
10-15 Deg C. After the vernalization treatment the temperature was raised.
Originally there were two (!) plants, but one perished, Lysenko said as
a result of pests, The sole surviving plant matured on September 9, proving
to Lysenko that vernalization worked, since Kooperatorka normally matures
in the spring... All that can be concluded from such an experiment is that
Lysenko's methods were incredibly lacking in rigor. The ridiculousness
of basing scientific conclusions on a sample of two need not be emphasised."
p. 204-5.
Also it shoudl be noted, that within this general area, ample
data accumulated since Lysenko's time, confirms the view that developmental
signals or cues, are critical to a whole series of later developmental
paths.
Briggs and Walters provide many examples whereby developmental
variability is directly associated to later phenotypic variation. Thus
they examine the phenomenon of Heteroblastic development. This was
a term coined by Goebel (1897) to denote the change form a juvenile to
an adult form phase accompanied by more or less abrupt changes in morphology:
"If we investigate closely the detailed development of
a plant with an adult leaf clearly different from that juvenile, the commonest
situation is likely to be shown in the Figure below (See Figure 11) for
Ipomoea caerulea, the Morning Glory, a common tropical climbing herb. In
this illustration taken from Njoku (1956) the top line shows the shape
of the first 10 leaves of a plant grown in the shade, and the second line
shows the came series from a plant in full daylight. Here two things are
evident : first, that the development of the adult three-lobed leaf-shape
is gradual; and secondly that the onset of the three-lobed leaf-shape in
the developmental series is greatly modified byu the environment, in this
case by light. Fig also illustrates the effect of the transferring the
plant from the shade to light at the stage of the unfolding of the second
leaf, and also of transferring it from light to shade. In both cases there
is a ' time-lag' ion reaction which lasts until the sixth or seventh leaf,
suggesting that the developmental processes which determine the form of
the mature leaf are operating at an early stage in the differentiation
of leaf primordia on the growing point, and that once these have reached
a certain stage the effect of environmental factors is no longer operative.
The important point to note is the irreversibility of change at a certain
stage in the development of mature structures and its relation to developmental
variation."
Briggs and Walters. Ibid, p.108-9.
Figure 11. Njoku's experiment
with Ipomoea caerulea
From, Figure 6.11 From Briggs
and Walters, Ibid, p. 108.
3. THEORY AND PRACTICE
Lysenko felt that both theory and practice were crucial
to interpret the natural world correctly.
It is interesting to note that Darwin, maintained consistently
how much he learnt from the practical breeders.
Similarly, it is also interesting that Barbara McClintlock
was herself looked down upon by many scientists in the USA, on the grounds
that she was only a breeder. In fact for further development of her work,
McClintlock needed the aid of techniques developed by breeders. McClintlock
wished to associate particular genes with particular chromosomes:
"At that time there were two forms of geneticists :the
breeder who did nothing but breeding, and the person who worked on chromosomes.
They did not get together - they even worked in separate places."
Keller; Ibid; p.45.
But, undoubtly, there was a tendency amongst the Lysenkoist
to ignore the role of carefully controlled experimentation.
For example, Lysenko asked :
"Do we have the right when we propose a method that is
as yet only theoretically grounded .. to lose two or three years in preliminary
trial of this method on little plots at several plant-breeding institutions?
No, we haven't the right to lose even a single year."
Cited Joravsky, Ibid. p.277.
If adequate controls are not built into an experiment,
it is likely that misinterpretation will occur.
It seems to be the case that the Lysenkoists were not
able to carefully document their work with as many controls as science
should expect.
4. THE MATERNAL ENVIRONMENT
Lysenko believed that the maternal environment was of
utmost importance in the development of the progeny. It is of interest
that in many animal species (from drosophila flies to Xenopus amphibians,
to mammals) the early fate of the early embryo is linked to the maternal
contributions to the zygote.
Early on, Boveri, a pioneer of developmental biology,
whose other contributions included recognition of the importance of chromosomes,
had realised that the maternally derived cytoplasm plays a general organising
role for the developing zygote after fertilisation.
This seemed in any case logical, since the sperm arrived
with very little cytoplasm, whereas the egg was often very large. Interestingly,
his classic experiments on "merogonic hybridisation", were performed to
prove conclusively that there was no role for the cytoplasm in inheritance:
"Essentially they consisted of fertilising sea urchin
egg fragments lacking a nucleus with the sperm of a different species of
echinoderm, having characteristically different larva. If the embryo showed
only characteristics of the paternal species bought in by the sperm, the
nucleus would be considered to be the sole "bearer of inheritance". however
characteristics of the maternal type appeared as well, a cytoplasmic influence
must be operative. In his first paper, Boveri reported that the larvae
resulting from the fertilisation of a presumably enucleated egg of one
kind of echinoderm with the larva of another possessed larval features
of the male parent only. His conclusion was clear enough:
"Herewith is demonstrated the law that he nucleus alone
is the bearer of hereditary qualities."
Sapp Ibid, p. 15
Sapp comments that:
"Although Boveri's first conclusion was precise, his
supporting results were not. Indeed they were quite ambiguous and were
questioned by Morgan and others."
Sapp, Ibid. P. 15
Finally, as a result of his experiments, Boveri concluded:
"I would like to ascribe to the cytoplasm of the sea
urchin embryo only the initial and simplest properties responsible for
differentiation.. the structure of the egg cytoplasm takes care.. of the
purely 'promorphological' tasks, that is provides the most general basic
form, the framework within which all specific details are filled in by
the nucleus."
Boveri, Cited by K.V.Anderson, in "Drosophila: the maternal
contribution " In Ibid, p. 1.
But it is true, that some cases of "maternal inheritance",
proved to be not very convincing as refutations of the Mendelian-Morgan
hypothesis of primacy and monopoly of the nucleus.
Thus the cases of Toyama's silkworms and Boycott's snails
were seized by Sturveyant to attack so called maternal inheritance.
Toyama had:
"In 1913.. reported.. that egg characters which at first
appeared to be "non-Mendelian" ultimately could be attributed to Mendelian
genes. .. When races of silkworms which possessed characteristic but different
egg markings, such as shape, colour, etc were crossed, the characteristics
of the egg hybrid were like those of the maternal race only. However when
the adult F1 were raised from the these eggs, and when they in turn produced
embryos, the distribution of egg characteristics was no longer solely maternal
and could be explained by Mendelian mechanisms."
Sapp, p. 27.
Similarly for the previously described molluscs reverse forms,
(ie Left handed spirals or right handed spirals) of shell coiling:
"A similar case of "maternal inheritance" was reported
in the gastropod Limnae peregra. .. the reverse forms of symmetry .. had
been understood by E.G.Conklin to represent a " fundamental " character
of the organism due to the organisation of the egg cytoplasm. However in
1923 A.E. Boycott and C.Diver.. reported result which suggested
that the inheritance of dextral and sinistral coiling in the snail was
an illustration of "maternal" inheritance that was nevertheless dependent
upon the chromosomes. The American geneticist A.H.Sturveyant seized
upon this work. Responding to the threatening view that the Mendelian genes
controlled only trivial characters, he wrote in a review of the work published
in Science:
'It seems likely that we shall have a here a model case
of the Mendelian inheritance of an extremely fundamental character, and
a character that is impressed on the egg by the mother."
Sapp, p.27-8
But modern day genetics has accepted the notions of maternal
inheritance as being an important developmental control. Anderson comments
that:
"As a result of recent genetic studies it can be concluded
that in drosophila, as well, maternally provided components defined the
basic spatial organization of the embryo, and that the detailed pattern
is the result of the activity of the zygotic nuclei.. The characterisation
of maternal-effect mutations has demonstrated the involvement of maternally
encoded gene products in a wide range of embryonic processes including
early nuclear division, nuclear migration, cellularization, gastrulation,
definition of the polarity of the body axes, segmentation, neurogenesis
and segment identification."
Anderson, Ibid. p. 1-2.
In the Xenopus laevis and other frog and amphibian, the knowledge
of the different poles of the embryo has led to searches for the differences
in composition. There seems to be a definite polarity in the presence of
different maternally acquired cytoplasmic determinants. These include nucleic
acids, and are distributed asymmetrically in the developing embryo, after
fertilisation:
"The Xenopus egg has a visually conspicuous polarity
along its vertical axis. The upper or animal hemisphere is heavily pigmented
and the lower or vegetal hemisphere is not. There is also internal animal-vegetal
polarity, The vegetal hemisphere is packed with a dense array of large
yolk platelet, while the animal cytoplasm has much smaller platelet and
less yolk overall, In the oocyte the germinal vesicle is located in the
animal hemisphere.. While most tissue differentiation depends upon inductive
interactions, there are three examples of specification that are probably
due to inheritance o egg determinants (ie. Leading to cellular commitment
by cytoplasmic determinants -ED) : epidermis formation from animal cells;
primordial germ cell specification by vegetal pole germ plasm; and the
transient capacity of vegetal blastomeres to induce animal cells to become
mesoderm.. awareness of the animal and vegetal specific autonomous developmental
fates discussed above has prompted extensive searches for informational
molecules that could serve as determinants.. the search has focused on
maternal RNAs.. Indications that some maternal poly(A)+ RNA's might be
distributed unevenly came for the work of Carpenter and Klein who prepared
egg animal and vegetal pole poly(A)+ RNA and CDNA used this material in
solution hybridisation experiments. They found that 3-5% of the vegetal
poly(A)+ RNA was 2-20 fold less abundant and possibly absent in the animal
pole.. King and Barklis.. found 5 protein species in the 16-26 KD range
and each representing 0.04-0.3% of the mRNA pool, appeared to be highly
specific to the vegetal fraction. Rebagliati.. identified 4 different mRNAs
that have specific localizations : 3 AN1, AN2, An3, were largely confined
to the animal pole; and one Vg1 to the vegetal pole.. VG1 encodes a polypeptide..
in a family of genes that includes TGF-B.. which is involved in the induction
of dorsal and perhaps ventral lateral mesoderm during blastula and early
gastrulation in Xenopus."
p.132-135. T.D.Sargent, Xenopus. In "Genes and Embryos"
Ed D.M. Glover and B.D. Hames. IRL Press, Oxford, 1989.
Higher animals such as the mammals have similar special effects
from the maternally derived egg molecules:
"One cell mouse embryos treated with inhibitors of protein
synthesis do not cleave, indicating that de novo translation is necessary
for development to proceed. On the other hand, inhibiting zygotic transcription
with a-amanitin allows the first cleavage to proceed, but the embryos arrest
at the two-cell stage. Maternal RNA is therefore exclusively used only
briefly during development. On the other hand zygotic transcription in
humans does no begin until the 4-8 cell stage, and in sheep until the 16
cell stage. Degradation of mRNA occurs concomitantly with the onset of
zygotic transcription."
p.171. I.J.Jackson. "The Mouse" in "Genes and Embryos"
Ed D.M. Glover and B.D. Hames. IRL Press, Oxford, 1989.
Following from this general recognition of the importance
of the maternal environment, it was natural that the concept of phasic
development would follow. At certain critical stages in development,
the "set conservative" path of the developing embryo could be changed to
another path.
There are critical periods when it is best
to perform these experimental manipulations:
There are parallels in Western biology. Thus many workers
were interfering with normal development by environmental manipulations:
"During the 1930's Jollos reported that when fruit flies
were exposed to a high temperature in the larval stage, hereditary alterations
occurred. Goldschmidt coined the word phenocopy to describe a change which
was not a gene change but which had the same appearance as a gene mutation.
Jollos' work on heat resistance and other induced traits in Paramecium
(Dauermodifikationen) where the environmentally directed adaptive hereditary
cytoplasmic changes gradually faded away, were.. confirmed by many investigators."
Cited Sapp. p.168.
Experimental data amply confirms the notions in this theory.
They address one of the concerns that Weissmann had articulated in his
erection of the Central Dogma. This was that if the developing embryo was
open to environmental challenge, that development would be possibly disrupted.
Lysenko pointed out that indeed there was a conservatism
to respect of development, but that in careful manipulation, that the conservative
patterning of the embryo could be broken.
It appears that in this matter, Lysenko was indeed
correct.
5. SPECIATION.
According to Lysenko, the:
"Conversion of one species into another takes place by
a leap."
p.48, Ibid; Address to the Lenin Academy.
His views were most clearly opposed by Vavilov, whose
alternative views are discussed below.
But it should be recognised that Lysenko's view is not
dissimilar from many then contemporaries of Lysenko such as Goldschmidt;
and moreover many present day Western geneticists.
Recently, as discussed above, the theory of Saltatory
species formation of S.J.Gould and Niles Eldredge) change acknowledges
rapidity in species formation.
Vavilov developed his Theory of "The Law of Homologous
Series", and unveiled it in June, 1920 at the Conference of Breeders:
"The biological equivalent, he said of the periodical
table of chemical elements."
p.31. Joravsky J of Genetics 1922:12 , 48-89.
According to Gould:
"Vavilov was perhaps the world's leading expert on the
biogeography of wheat and other cereals."
SJ Gould ."A hearing for Vavilov ", in: "Hen's teeth
and Horse's Toes " p.134-144.
In his work he had collected specimens from all over the
world, establishing a bank (the largest in the world ) of genetic variation.
He observed:
"Strikingly similar series of varieties could be found
within the different species of a genus and often within species of related
genera as well."
Ibid p.136.
From changes in rye and wheat specimens from Europe, Asiatic
Russia, Iran and Afghanistan, Vavilov concluded that:
"He could predict the existence of undiscovered varieties
within one species after finding their parallel forms in another species."
Ibid; p.137.
He indeed correctly predicted the existence of certain varieties:
"Several varieties of wheat without ligules are found
in Afghanistan (ligule are thin membranes that grow from the base of the
leaf blade and surround the stem in many grasses). This.. suggested that
varieties of rye without ligule should also exist, and he grew them from
seeds collected in Pamir in 1918. He predicted that durum wheat (triticum
durum ) then represented exclusively by spring varieties, should also have
winter forms since related species do - and he found them in 1918 in an
isolated region of Iran."
Ibid p.137.
The normal explanation of these findings would invoke parallel
evolution in response to a similar environment. However Vavilov proposed:
"Parallel series of varieties represented identical responses
of the same genetic systems, inherited in toto from species to related
species. Thus.. his series were " homologous ". Homologies are similarities
based on inheritance of the same genes or structures from a common ancestor.
Similarities forged within different genetic systems by selective pressures
of similar environments are called analogies."
Gould, Ibid, p.137.
Thus Vavilov argued that new species arose by developing
genetic differences that precluded interbreeding. But most of the ancestor's
genetic system was intact and the same, leaving not much difference between
them:
"The parallel varieties then represent a 'playing out'
of the same genetic capacities inherited as blocks from species to species."
p.138.
The theoretical consequences of this are pointed out
by S.J. Gould :
"What if variation is not fortuitous and undirected but
strongly channelled along certain paths? Then only a limited number of
changes are possible, and they record the "internal" constraints of inheritance
as much as the action of selection. Selection is not dormant : it still
determines which of several possibilities reaches expression in any one
climate or area. But if possibilities are strictly limited, and if a species
displays all of them among its several varieties, then this range of for
cannot be ascribed only to selection acting upon fortuitous variation.
Moreover this explanation for new varieties compromises the cardinal principle
of creativity for natural selection. The variations are predictable results
within their genetic system. Their occurrence is almost foreordained.
The role of natural selection is negative. It is an executioner only.
It eliminates the variants unfit in any given environment, thus preserving
the favoured form that had to arise eventually. Vavilov interpreted his
law .. in this non-Darwinian manner."
Ibid; p.138.
Thus in discussing lentils Vavilov says:
"The same varieties certainly existed long before selection
itself, and the appearance of their series irrespective of any selection
was in accordance with the laws of variation."
Ibid; p.139
Extrapolating his ideas lead Vavilov to predicting an ordering
of biological "elements", that would enable precise construction of organisms.
An explicit analogy with the Periodic Table in chemistry predicted that
:
"New forms have to fill vacancies in a system."
Ibid; p.139-40.
In opposition Lysenko charged that Vavilov's Law :
"Located the source of organic change within the genetic
systems of organisms themselves and not in the interaction (or dialectic)
between organism and environment; and secondly.. that the law of homologous
series was "idealist" rather than materialist because it viewed the evolutionary
history of a species as prefigured onto the unrealized and therefore unmaterial
capacity of an inherited genetic system."
Ibid; p.141.
S.J. Gould acknowledges only that:
"We must admit that Lysenko did identify and exploit
the true weaknesses in Vavilov's argument. Vavilov did underplay the creative
role of environment, and his chemical analogy did betray a belief in prefigured
potentiality as the source of alter, and in some sense illusory, change."
Ibid; p.141 .
This grudging admission is similar to remarks made upon the
discovery that sometimes Lysenko may be right and his opponents wrong.
However, S.J. Gould does go on to conclude that:
"A complete theory of evolution must acknowledge a balance
between "external" forces of environment imposing selection for local adaptation
and "internal" forces representing constraints of inheritance and development.
Vavilov placed too much emphasis on internal constraints and downgrade
the power of selection. But Western Darwinians have erred equally in practically
ignoring (while acknowledging in theory) the limits placed upon selection
by structure and development - what Vavilov called laws of "form". We need
in short a real dialectic between the external and internal factors of
evolution."
Gould, Ibid, p.144.
This implicitly sees the Deification of Natural Selection
created by the Western Darwinians.
It acknowledges the difficulties, that are created by
a dogmatic insistence upon all change in evolution being purely random
(ie by chance); until such time that it be fixed by Natural Selection.
Of course as discussed in Part 1, Gould was one of the
dialectical biologists who have brought forward the Punctuated Equilibria
story.
CONCLUSION
The substance of Lysenko's views on speciation regarding
rapidity of formation, are still controversial. However a growing body
of conventional main stream biologists and geneticists are in broad agreement
with this view that species formation is a much more rapid event than given
credit by the New Synthetists.
6. THE ORIGINS OF LIFE : OPARIN,
A DIALECTICIAN REFUTES LEPESHINKAIA : A REDUCTIONIST MATERIALIST.
Lysenko's school initiated a whole series of attempts
to explain biology by a prior philosophical commitment to dialectics.
The invocation to explain everything by Dialectics, was
taken up by a number of individuals, some of whom were not adequately critical,
or adequately scientifically trained. This had a tendency to lower the
standard of science by posing questions in a very mechanical manner.
This general approach in starting from a prior commitment,
and then proceeding to obtain data can be quite different to the approach
of seeing events first, and then explaining them.
This process of explanation can either take into account
an understanding of dialectics; or it can ignore dialectics.
The two approaches are conceptually quite different, and
may lead to differing solutions. But it is true that there is both a postive
and a negative in this Prior commitment. The negative lies in a prior Bias
(expectation). The positive lies in an ability to ask the right questions.
But unless, the balance is kept, the result can be a half-baked
Mechanical Materialism. This seemed to have happened in a number of instances.
The half-baked solution was often superficial more attractive becasue it
aspired to being Dialectical, and was often easily achieved. The more real
dialectical solution was however more difficult to achieve.
A particular instance where the two approaches differed,
was in the debate on the Origins of Life. here Oparin
was a scientist who was early on credited with first realising a key issue.
This was that the origins of life, must have been in a climate radically
different from present physico-chemical conditions on Earth.
The differences in the two approaches can be exemplified
by comparing Oparin with Olga Lepeshinskaia.
The latter was a scientist, who worked out of her kitchen,
and pushed a claim that she had engendered Spontaneous generation. Naturally,
this observation was exciting if it could be replicated. Unfortunately
it could not. The two certainly at core disagreed:
"Oparin's major points concerned his belief in the erroneousness
of the concept of the spontaneous generation. The book by Olga Lepeshinskaia,
The Development of Cells From Living Matter, was in his opinion,
'An attempt to rehabilitate Pouchet's experiments
and thus to resuscitate the theory of spontaneous generation'.
Pouchet had expected microorganisms to be spontaneously generated;
Lepeshinskaia also looked for spontaneous generation, but of cells for,
noncellular matter instead of complete organisms. Both had therefore sought
the sudden appearance of order out of chaos, and such attempts are 'foredoomed
to failure'. The formation of the very 'complicated structure of protoplasm'
that is contained in both microorganisms and the single body cannot have
happened fortuitously, but rather as the result of a long evolutionary
process.."
Graham 1, Loren. "Science and philosophy in the Soviet
Union." New York, 1974 p.279.
The difficulties in Spontaneous Generation were first
appreciated by Pasteur, whose travails were early noted by Engels. Oparin
took the more subtle, but more productive approach to Engels' writings:
"A famous debate in the 1860's between the French scientist
Felix Pouchet and Louis Pasteur over the possibility of the spontaneous
generation in disrepute for the remainder of the century. ..Frederich Engels
observed ironically:
'that it would be foolish to expect men with the help
of 'a little stinking water to force nature to accomplish in 24 hours what
it has cost her thousands of years to bring about.'
..Pasteur himself commented in 1878:
'Spontaneous generation? I have been looking for it for
20 years, but I have not yet found it, although I do not think it is an
impossibility."
Graham 1, Loren. Ibid, p. 259.
By 1936 Oparin had digested and was citing Engels' Dialectics
of Nature.
In the process he more or less anticipated, and openly
repudiated the possibility of the future "findings" such as those of Lepeshinskaia
:
"He commented that Engels had 'subjected the theory of
spontaneous generation and the theory of eternal life to a withering criticism.'..
Oparin now thought any effort to explain the 'sudden generation of organisms'
could only rely on either a act of 'divine will' or 'some special vital
force'. Such a view is entirely incompatible with the materialistic world
conception.
"On the contrary : 'Life has neither arisen spontaneously
nor has it existed eternally, it must therefore have resulted from a long
evolution of matter, its origin being merely one step in the course of
its historical development."
Graham, Ibid p.272.
As he went on, Oparin had no hesitation about updating Engels.
In this he soon had problems with the "Ultra orthodox dialectical materialists"
who wished to stick to Engels' literal words, including the word "protein"!
These were the "Ideologically Pure" who under this guise
prevented grappling with the real dialectical issues:
"When Engels said: 'Life is a form of the existence of
protein bodies,' He did not intend to say, Oparin said, that 'protein is
living matter.' Instead he meant that protein has hidden in its chemical
structure 'the capacity for further organic evolution which under ceratin
conditions, may lead to the origin of living things.'..This emphasis on
process, on 'coordinated chemical reactions', rather than on determinate
structure, would eventually involve Oparin in controversies from two quite
different camps: The Ultra-orthodox dialectical materialist who wished
to stick to Engels literal word-"Protein"- as the essence of life, and
the new molecular biologists who saw the essential features of life in
the structure of nucleic acid and whose very terms of its description-
"template", "Code"- carried the sense of the static."
Graham 1, Ibid. p.273.
Oparin openly adopted Dialectical Materialism as an aid in
understanding the processes. This was recognised even by the biologists
of the West, who had appreciated his original and penetrating insights.
In a book that was actually translated by the United States space agency,
NASA, Oparin in 1966 wrote :
"Regarding life as qualitatively special form of the
motion of modern dialectical materialism formulates even the very problem
of understanding life in a different way than does mechanism. For the mechanist,
it contains of the most comprehensive reduction of living phenomenon to
physical and chemical processes. On the other hand from the dialectical
materialist point of view, the main point in understanding life is to establish
its qualitative difference from other forms of motion of matter. Life finds
its clearest expression (as a special form of the motion of the matter)
in the specific interaction of living systems -organisms- with the environment
surrounding it, is the dialectical unity of a living body, and in the conditions
of its existence.."
Graham 1, Loren. Ibid,p.261.
"In 1960 he commented, "Our bodies flow life rivulets,
their material is renewed like water in stream, This is what the ancient
Greek dialectician Heraclitus taught. Certainly the flow, or simply
the stream of water emerging from a tap enables us to understand in their
simplest form many of the essential features of such flowing or open systems
as are represented by the particular case of the living body."
Graham 1, Loren. Ibid, p.269.
Clearly since in this time both Lysenko and Oparin were receiving
Support from the CPSU(B), even though this author believes that they were
from different wings of the party, the two were bound to be connected in
some way:
"Politically Oparin and Lysenko were linked however far
apart they might have been in intellectual sophistication. Both had won
favour from the Stalinist regime, both had built their careers within it..
Oparin was active in Soviet political causes in international organisations..
The Soviet biologist Medvedev wrote in his history.. that in 1955 a petition
against the administrative abuses of both Lysenko and Oparin was circulated
among Soviet scientists, Oparin was for many years a supporter of Lysenko,
praising him in print on numerous occasions. Nonetheless.. Oparin struggled
against several attempts by sympathizers with Lysenko to invade Oparin's
field. Medvedev reported that in the final struggle with Lysenko, Oparin
took a neutral position."
Graham, Ibid. p 275.
In light of the administrative and other connections between
Oparin and Lysenko, the initial support Oparin gave to Lepeshinskaia could
be construed as opportunism. It is unclear however, whether he was ever
genuinely convinced by her claims of what amounted to spontaneous generation.
"In 1951 Olga Lepeshinskaia proclaimed a new cell theory.
Lepeshinskaia was a mediocre biologist of impressive political stature
as a result of he membership in the CPSU(B) from the very date of its founding
and of her personal relationship with Lenin..In 1950 Lepeshinskaia claimed
that she had obtained cells from living noncellular matter. Lepeshinskaia
even maintained that she had obtained cells form noncellular nutrient mediums
in as short a time as 24 hours. Her work won praise from Lysenko himself..
It should be obvious from the past discussion of Oparin's views that he
was sceptical in the extreme.. Engels had appropriately ridiculed those
people who thought that they could compel nature in 24 hours that for which
thousands of years had been necessary. On principle, of course, such an
event was possible, but Oparin thought only the best evidence, repeatedly
substantiated would hay been convincing.. But in 1951.. Oparin succumbed..
and praised the "great service" of Professor Lepeshinskaia in "demonstrating"
the emergence of cells from living non-cellular matter.. not until 1953
did Oparin begin to resist these views in print, By 1957 he had returned
to his flat opposition to spontaneous generation and to.. Lepeshinskaia."
Graham 1, Ibid, p.276
Graham claims that in later face-to-face interview with Oparin,
Oparin opined that: "It was easy for Americans to criticise his support
for Lysenko," but that in effect there was no choice if he wished to continue
his scientific work and avoid censure and possibly more (See Graham 2,
Bibliography).
Finally, Oparin did resist the crude reductionist materialist
attempts. In fact Oparin was a firm adherent of dialectics. This continued
through his controversies with Western scientists into the 1960's. His
criticisms of crude reductionist materialism are also an sharp critique
of Lepeshinskaia. That his struggle in theory, was conducted in such a
veiled manner, is highly indicative of the "unhealthy" climate that Dogmatists
had created in the name of Dialectical Materialism.
The political events behind this Facade of Dialectics
is discussed below in Part Four.
However, Stalin tore away the facade, when he exposed
how it was used to cover a crude "arrogance" and dictatorial style in the
science of Linguistics. All in the name of "Dialectics".
This may make some quite unhappy about the possibilities
inherent in Dialectics. However, that it is a TOOL that can be misused,
like any other, should not discredit it. In Part Three we try and draw
out some of the ways in which an application of Dialectics aids Biology.